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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 12.42
Human Site: S687 Identified Species: 17.08
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S687 A L K L P I P S P Q R A F T L
Chimpanzee Pan troglodytes XP_001165585 1017 111787 G687 A L K L P I P G P Q R A F T L
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 G808 A L K L P I P G P Q R A F T L
Dog Lupus familis XP_543550 1017 111618 G687 A L K L P M P G P Q R A F T L
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 G685 A L K L P I P G P Q R A F T L
Rat Rattus norvegicus NP_001129232 1015 111665 G685 A L K L P I P G P Q R A F T L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 I693 A L K L P T P I P Q K S F T L
Frog Xenopus laevis Q8QFR2 1013 112021 T683 T L R L P T P T P Q K S F T L
Zebra Danio Brachydanio rerio XP_696478 1010 111223 S680 V L K L P T P S I Q K S F S T
Tiger Blowfish Takifugu rubipres O42611 1025 111838 S695 A L K L P T P S I K K A F T L
Fruit Fly Dros. melanogaster O17468 1047 113397 F705 Q G M P L I G F P S G N S Y S
Honey Bee Apis mellifera XP_001122939 838 91355 E526 K K P K I T S E R N T N Q I I
Nematode Worm Caenorhab. elegans Q09589 935 103412 T623 K H G G V E T T Q I K L I K K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 K652 W S D R I S G K V T V L A G N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 Y708 V T R K G S L Y V W D L F N R
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 K528 K R I E N N V K S S T K T I N
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 L686 T A T K R G A L L W Q D F L P
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 93.3 93.3 86.6 N.A. 93.3 93.3 N.A. N.A. 73.3 60 53.3 73.3 13.3 0 0 N.A.
P-Site Similarity: 100 93.3 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. 86.6 86.6 73.3 86.6 13.3 6.6 13.3 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 0 N.A. 6.6 0 6.6
P-Site Similarity: N.A. 0 N.A. 13.3 0 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 48 6 0 0 0 0 6 0 0 0 0 42 6 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 6 0 0 0 0 0 0 0 6 6 0 0 0 % D
% Glu: 0 0 0 6 0 6 0 6 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 6 0 0 0 0 71 0 0 % F
% Gly: 0 6 6 6 6 6 12 30 0 0 6 0 0 6 0 % G
% His: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 6 0 12 36 0 6 12 6 0 0 6 12 6 % I
% Lys: 18 6 53 18 0 0 0 12 0 6 30 6 0 6 6 % K
% Leu: 0 59 0 59 6 0 6 6 6 0 0 18 0 6 53 % L
% Met: 0 0 6 0 0 6 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 6 6 0 0 0 6 0 12 0 6 12 % N
% Pro: 0 0 6 6 59 0 59 0 53 0 0 0 0 0 6 % P
% Gln: 6 0 0 0 0 0 0 0 6 53 6 0 6 0 0 % Q
% Arg: 0 6 12 6 6 0 0 0 6 0 36 0 0 0 6 % R
% Ser: 0 6 0 0 0 12 6 18 6 12 0 18 6 6 6 % S
% Thr: 12 6 6 0 0 30 6 12 0 6 12 0 6 53 6 % T
% Val: 12 0 0 0 6 0 6 0 12 0 6 0 0 0 0 % V
% Trp: 6 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 6 0 0 0 0 0 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _